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Sunday, October 25, 2009

Moodswings as a result of medication?

I have Budesonide as an anti-inflammatory drug, but can it cause mood swings?
Answer:
Yes, absolutely. Corticosteroids mimic the stress hormone cortisol, so they affect mood. Most patients don't reach full-blown mania or depression, but some do. Budesonide supposedly has less side effects than older meds (prednisone), but I haven't actually seen a study on it.
cushings syndrome and other if blood level of cortisone too high or low.

see your MD.

I'd say" less serious" is a matter of personal opinion.

Other, less serious side effects may be more likely to occur. Continue to take budesonide inhalation and talk to your doctor if you experience

dry mouth, nose, or throat after use;
yeast (or another) infection in the mouth or throat (white patches);
hoarseness or deepening of the voice, cough, or sore throat;
headache;
weakness or fatigue;
weight loss;
increased tanning of the skin;
lightheadedness or dizziness;
unpleasant (or loss of) taste or smell;
nausea or abdominal pain;
decreased growth in children taking large doses;
increased pressure in the eyes, glaucoma, or tearing of the eyes;
cataracts, which may develop after long-term use; or
mood changes such as depression, aggression, irritability, or anxiety (these effects are very rare).
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Is this for asthma?
Budesonide is a glucocorticosteroid with a high local anti-inflammatory effect.
The steroid effect can cause some psychiatric disturbances such as restlenssness, behaviours changes etc but usually in higher doses or prolonged use... I would suggest you see your doctor again and look at some other similar e.g. Fluticasone propionate
Glucocorticoids like budesonide have long produced stories of triggering episodes of depression, mania and mood swings. In fact, although no studies have found any convincing evidence that this is true, most physicians have heard so many stories that they still believe this is true.

Obviously, there is some amount of controversy, but it is not impossible that your mood changes may be related to the medication. On the other hand, there is a good chance they are totally unrelated. An unsatisfying answer, yes, but that is the limit of the truth right now.

As always, discuss these and any questions with your doctor.

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