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Tuesday, May 25, 2010

Prolonged Fasting result in Falsely elevated Triglycerides?

Hihi.. I have been looking for infos on the impact of prolonged fasting( %26gt; 14hrs) effects on triglycerides. Does anyone know how much effects it can have on triglycerides? What is the metabolic pathway involved that helps the liver breaks down "something" to produce tryiglycerides so the TG will be falsely increased under prolonged fasting(eg like starvation). Is the TG increase dramatic? Is this not reccomanded when a fasting lab test is necessary?
Can anyone explain the metabolic pathway? thx !~ i have returned my biochem to my lecturer.. =x

Anyone from lab wish to share some experience? =)
Answer:
The pathway is lipolysis and reesterification. Adipocytes release free fatty acids (not TG's) which are taken to the liver for making energy, namely ketone bodies during starvation. Some FFA's are stuck back together to be released as TG's in VLDL's (very low denstiy lipoproteins).
In the liver triglycerides (from blood or diet) are broken down into lipids and glycerol. These can be converted into glucose or ketone bodies. Some other tissues can utilize intrinsic TG's but I am not sure how useful they are immediately from the bloodstream and during starvation.
In blood tests you can get a high TG value from fasting 12-24 hours but a severe hyperlipidemia is apparent in a markedly starved animal (humans are animals, too). There are suggested cut-offs in vet med based on percentages of normal values to determine whether an animal is currently starving (or just fasting).
Hope that helps

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